منابع مشابه
Solubilization pdf
PURPOSE: Micellar solubilization is a powerful alternative for. Done regarding solubilization of drugs by micelles is presented. Abstract: In this paper, the use of surfactants for solubilization of. solubilization techniques pdf Polyelectrolytes, pH, and temperature on dye solubilization has been.Solution chemistry, solubility and solubilization. Dissolution limited bioavailability is a very c...
متن کاملSolubilization of Peptides
ity. The amino acid composition will provide a fi rst indication: before choosing a solvent, the sequence should be studied and the number of acidic, basic and neutral residues should be determined. The side-chain functionalities of acidic and basic amino acids will be charged at physiological pH. The nature of the Nand the C-terminal functionality has to be taken into consideration. The neutra...
متن کاملSolubilization of vorinostat by cyclodextrins.
BACKGROUND Vorinostat (suberoylanilide hydroxamic acid) is the first histone deacetylase inhibitor approved by US FDA for use in oncology. However, as a hydrophobic acid, its limited aqueous solubility poses a problem for parenteral delivery. Such limited solubility may also affect its oral bioavailability. OBJECTIVE The aim of this study was to evaluate whether cyclodextrins (CDs), common ex...
متن کاملBiotinylated Cyclooligosaccharides for Paclitaxel Solubilization.
The poor water solubility of paclitaxel causes significant problems in producing cancer therapeutic formulations. Here, we aimed to solubilize paclitaxel using biocompatible cyclic carbohydrates. Generally recognized as safe, labeled β-cyclodextrin (β-CD), a cyclic α-1,4-glucan consisting of seven glucoses, was prepared, and bio-sourced cyclosophoraoses (CyS), which are unbranched cyclic β-1,2-...
متن کاملSolubilization of functional calcitonin receptors.
Calcitonin (CT) binding activity has been extracted from a membrane fraction of human placenta using the zwitterionic detergent, 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulphonic acid (Chaps). Approximately two-thirds of the available binding sites were extracted using 5 mM-Chaps. The binding characteristics of 125I-labelled salmon CT(125I-sCT) to the solubilized extract were similar to...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 1974
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.49.1.80